Chemical Structure : STAT3 inhibitor K116
CAS No.:
315670-31-6
STAT3 inhibitor K116
Catalog No.: PC-24431Not For Human Use, Lab Use Only.
K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
K116 is a potent allosteric inhibitor specifically targeting the STAT3 coiled-coil domain (CCD), selectively inhibits the phosphorylation of p-Y705STAT3 in breast cancer cell lines.
K116 selectively inhibited the proliferation of breast cancer cells.
K116 (20 μM) directly monitored STAT3 stabilization and engagement within MDA-MB-468 cells, without affecting STAT1, STAT5, and Akt1.
K116 induced apoptosis and inhibited migration as well as pY705STAT3 nuclear translocation and transcriptional activity of STAT3.
K116 (30 mg kg−1) markedly suppressed tumor growth and inhibited STAT3 activity in a 4T1 cell-derived murine breast cancer model.
Physicochemical Properties
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M.Wt
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276.31
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Formula
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C13H12N2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N'-(1-(2,4-dihydroxyphenyl)ethylidene)thiophene-2-carbohydrazide
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References
1. Huang M, et al. RSC Med Chem. 2025 Mar 24. doi: 10.1039/d4md00926f.
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