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Chemical Structure : NSC 368262
Catalog No.: PC-62863Not For Human Use, Lab Use Only.
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers.
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NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers.
NSC 368262 also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines.
NSC 368262 impressively inhibits tumor growth in mouse models.
| M.Wt | 410.426 | |
| Formula | C22H22N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Buettner R, et al. ACS Chem Biol. 2011 May 20;6(5):432-43.
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