ISS610 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : ISS610

ISS610 (ISS-610)

Catalog No.: PC-26446Not For Human Use, Lab Use Only.

ISS610 (ISS-610) is a selective peptidomimetic inhibitor of STAT3 dimerization with IC50 of 42 uM for STAT-DNA binding disruption, interacts with SH2 domain of STAT3 and shows 7.4-fold selective over STAT1.

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Biological Activity

Physicochemical Properties

M.Wt	503.45
Formula	C23H26N3O8P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((S)-2-(4-Cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanamido)-4-methylpentanoic acid

References

1. Shahani VM, et al. Bioorg Med Chem. 2011 Mar 1;19(5):1823-38.

2. Gunning PT, et al. Bioorg. Med. Chem. Lett. 2007;17:1875.

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ISS610 (ISS-610)

Biological Activity

Physicochemical Properties

References

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