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Chemical Structure : STAT5 inhibitor 17f
CAS No.: 2111834-61-6
Catalog No.: PC-61125Not For Human Use, Lab Use Only.
A novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $468 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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STAT5 inhibitor 17f is a novel potent, selective inhibitor of phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation.
STAT5 inhibitor 17f inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5.
STAT5 inhibitor 17f inhibits KU812 and K562 cell growth with IC50 of 9 and 5 uM, respectively, demonstrates highly potent antileukemic effect with minimal effects on bone marrow stromal cells.
| M.Wt | 397.522 | |
| Formula | C26H27N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2-((1H-Indol-5-yl)oxy)ethyl)-4,4-dimethyl-6-(pyridin-3-yl)-1,2,3,4-tetrahydroquinoline |
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1. Juen L, et al. J Med Chem. 2017 Jul 27;60(14):6119-6136.
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