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ML116

Chemical Structure : ML116

CAS No.: 744270-00-6

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ML116 (ML 116;ML-116)

Catalog No.: PC-60659Not For Human Use, Lab Use Only.

ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML116 is a selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM).
ML116 inhibits transcription of the STAT3-regulated gene BCL3, slectively induces loss of viability of breast cancer cell lines such as MDA-MB-468 cells.

Physicochemical Properties

M.Wt 309.431
Formula C18H19N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine

References

1. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69.

2. Madoux F, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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