Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-JAK/STAT Signaling-STAT-Angoline
Angoline

Chemical Structure : Angoline

CAS No.: 21080-31-9

Angoline (6-Methoxyldihydrochelerythrine)

Catalog No.: PC-24072Not For Human Use, Lab Use Only.

Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis.

Packing Price Stock Quantity
5 mg $78 In stock
10 mg $118 In stock
25 mg $218 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis.

Physicochemical Properties

M.Wt 379.41
Formula C22H21NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine

References

1. Jiawei Liu, et al. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

2. Su X, et al. Mater Today Bio. 2025 Jan 19;31:101497. 

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: