Chemical Structure : Angoline
CAS No.: 21080-31-9
Catalog No.: PC-24072Not For Human Use, Lab Use Only.
Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis.
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Angoline is a potent and selective inhibitor of IL6/STAT3 signaling pathway with IC50 of 11.56 uM, inhibits STAT3 phosphorylation and its target gene expression, also is an inhibitor of MORC2 protein, significantly kills the TNBC cells by blocking cell cycle and inducing apoptosis.
M.Wt | 379.41 | |
Formula | C22H21NO5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1,2,13-Trimethoxy-12-methyl-12,13-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine |
1. Jiawei Liu, et al. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.
2. Su X, et al. Mater Today Bio. 2025 Jan 19;31:101497.
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