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Narciclasine

Chemical Structure : Narciclasine

CAS No.: 29477-83-6

Narciclasine (Lycoricidinol)

Catalog No.: PC-28407Not For Human Use, Lab Use Only.

Narciclasine is a potent antimitotic substance isolated from Narcissus bulbs, blocks peptide bond formation by eukaryotic ribosomes, activates Rho and stress fibers in glioblastoma multiforme cells, modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway also degraders STAT3 by directly binding with the STAT3 SH2 domain.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Narciclasine is a potent antimitotic substance isolated from Narcissus bulbs, blocks peptide bond formation by eukaryotic ribosomes, activates Rho and stress fibers in glioblastoma multiforme cells, modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway also degraders STAT3 by directly binding with the STAT3 SH2 domain.

Physicochemical Properties

M.Wt 307.26
Formula C14H13NO7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one

References

1. Ceriotti G. Nature. 1967 Feb 11;213(5076):595-6.

2. Carrasco L, et al. FEBS Lett. 1975 Apr 1;52(2):236-9.

3. Lefranc F, et al. Mol Cancer Ther. 2009 Jul;8(7):1739-50.

4. Lv C, et al. Mol Ther Oncolytics. 2022 Jan 3;24:340-354.

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