Chemical Structure : Narciclasine
CAS No.: 29477-83-6
Catalog No.: PC-28407Not For Human Use, Lab Use Only.
Narciclasine is a potent antimitotic substance isolated from Narcissus bulbs, blocks peptide bond formation by eukaryotic ribosomes, activates Rho and stress fibers in glioblastoma multiforme cells, modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway also degraders STAT3 by directly binding with the STAT3 SH2 domain.
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|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
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| 50 mg | Get quote | ||
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Narciclasine is a potent antimitotic substance isolated from Narcissus bulbs, blocks peptide bond formation by eukaryotic ribosomes, activates Rho and stress fibers in glioblastoma multiforme cells, modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway also degraders STAT3 by directly binding with the STAT3 SH2 domain.
| M.Wt | 307.26 | |
| Formula | C14H13NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one |
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1. Ceriotti G. Nature. 1967 Feb 11;213(5076):595-6.
2. Carrasco L, et al. FEBS Lett. 1975 Apr 1;52(2):236-9.
3. Lefranc F, et al. Mol Cancer Ther. 2009 Jul;8(7):1739-50.
4. Lv C, et al. Mol Ther Oncolytics. 2022 Jan 3;24:340-354.

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