SIK3-IN-1 (Cmpd-219)

Chemical Structure : SIK3-IN-1

Catalog No.: PC-27828Not For Human Use, Lab Use Only.

SIK3-IN-1 (Cmpd-219) is a potent, selective salt-inducible kinase 3 (SIK3) inhibitor with IC50 of 10 nM, shows >50-fold selectivity over SIK1 and SIK2.

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Biological Activity

SIK3-IN-1 (Cmpd-219) is a potent, selective salt-inducible kinase 3 (SIK3) inhibitor with IC50 of 10 nM, shows >50-fold selectivity over SIK1 and SIK2.

Physicochemical Properties

M.Wt	458.44
Formula	C23H21F3N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-(2-cyanopropan-2-yl)pyrazolo[1,5-a]pyridin-3-yl)-2-(difluoromethoxy)-N-((1R,2S)-2-fluorocyclopropyl)-6-methoxybenzamide

References

1. Webb DT, et al. ACS Med Chem Lett. 2026 Jul 1;17(8):1795-1805.

2. Patent WO2020239658.

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SIK3-IN-1 (Cmpd-219)

Biological Activity

Physicochemical Properties

References

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