SIK3 inhibitor 39

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Chemical Structure : SIK3 inhibitor 39

Catalog No.: PC-27829Not For Human Use, Lab Use Only.

SIK3 inhibitor 39 is a potent, selective salt-inducible kinase 3 (SIK3) inhibitor with IC50 of 15 nM, shows 8-fold and 13-fold selectivity over SIK1 and SIK2 respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SIK3 inhibitor 39 is a potent, selective salt-inducible kinase 3 (SIK3) inhibitor with IC50 of 15 nM, shows 8-fold and 13-fold selectivity over SIK1 and SIK2 respectively.
SIK3 inhibitor 39 displays moderate selectivity for SIK3 over the other isoforms.
SIK3 inhibitor 39 possesses excellent kinase selectivity with S-score (50) of 0.043 across a general panel of 140 kinases.
SIK3 inhibitor 39 induced cytotoxicity in MV4-11 cells (GI50 = 1.2 μM).

Physicochemical Properties

M.Wt	478.50
Formula	C26H24F2N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,3-difluoroazetidin-1-yl)(4-(7-(2,6-dimethylpyridin-4-yl)imidazo[1,2-a]pyridin-3-yl)-2,6-dimethoxyphenyl)methanone

References

1. Webb DT, et al. ACS Med Chem Lett. 2026 Jul 1;17(8):1795-1805.

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