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Chemical Structure : rac Pterosin B
Catalog No.: PC-63124Not For Human Use, Lab Use Only.
rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.
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rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain.
rac Pterosin B shows no effect on up-regulation of MEF2 and down-regulation of CRTC2 activities by SIK1 or SIK2.
rac Pterosin B promotes glucose production by up-regulating gluconeogenic gene expression in mouse hepatoma AML-12 cells, decreases the glycogen content and stimulates an association between PHKG2 and SIK3.
| M.Wt | 218.296 | |
| Formula | C14H18O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Itoh Y, et al. J Biol Chem. 2015 Jul 17;290(29):17879-93.
2. Yahara Y, et al. Nat Commun. 2016 Mar 24;7:10959.
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