Chemical Structure : MRIA9
CAS No.:
2750707-05-0
MRIA9
(MRIA 9)
Catalog No.: PC-72723Not For Human Use, Lab Use Only.
MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively.
MRIA9 displays excellent selectivity in scanMAX kinase assay panel of 468 kinases.
MRIA9 sensitizes ovarian cancer cells to treatment with the mitotic agent paclitaxel.
MRIA9-induced inhibition of SIK2 blocks the centrosome disjunction, impairs the centrosome alignment, and causes spindle mispositioning during mitosis.
MRIA9 increases chromosomal instability in ovarian cancer cell lines.
Physicochemical Properties
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M.Wt
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495.939
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Formula
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C25H23ClFN5O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-3-(2-chloro-4-(3-fluoropyridin-2-yl)phenyl)-7-(methylamino)-1,6-naphthyridin-2(1H)-one
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References
1. Tesch R, et al. J Med Chem. 2021 Jun 24;64(12):8142-8160.
2. Raab M, et al. Cancers (Basel). 2021 Jul 21;13(15):3658.
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