Catalog No.: PC-21590Not For Human Use, Lab Use Only.
HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes. HG-9-91-01 significantly decreases proinflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-12p40) and increased IL-10 secretion by human myeloid cells stimulated with TLR2 and-4 agonists.
