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HG-9-91-01

Chemical Structure : HG-9-91-01

CAS No.: 1456858-58-4

HG-9-91-01

Catalog No.: PC-21590Not For Human Use, Lab Use Only.

HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes.
HG-9-91-01 significantly decreases proinflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-12p40) and increased IL-10 secretion by human myeloid cells stimulated with TLR2 and-4 agonists.

Physicochemical Properties

M.Wt 567.69
Formula C32H37N7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea

References

1. Sundberg TB, et al. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.

2. Patel K, et al. Nat Commun. 2014 Aug 4;5:4535.

3. Sundberg TB, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.

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