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Chemical Structure : HG-9-91-01
CAS No.: 1456858-58-4
Catalog No.: PC-21590Not For Human Use, Lab Use Only.
HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 100 mg | Get quote |
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HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes.
HG-9-91-01 significantly decreases proinflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-12p40) and increased IL-10 secretion by human myeloid cells stimulated with TLR2 and-4 agonists.
| M.Wt | 567.69 | |
| Formula | C32H37N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(2,4-Dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea |
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1. Sundberg TB, et al. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.
2. Patel K, et al. Nat Commun. 2014 Aug 4;5:4535.
3. Sundberg TB, et al. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73.
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