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Chemical Structure : ML-60218
Catalog No.: PC-61229Not For Human Use, Lab Use Only.
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
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ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively; compromises the structural integrity of viroplasms and rotavirus double-layered particles, interferes with the formation of higher order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize.
| M.Wt | 452.368 | |
| Formula | C19H15Cl2N3O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eichwald C, et al. J Virol. 2017 Nov 15. pii: JVI.01943-17.
2. Wu L, et al. Eukaryot Cell. 2003 Apr;2(2):256-64.
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