Chemical Structure : ML-60218
CAS No.: 577784-91-9
Catalog No.: PC-61229Not For Human Use, Lab Use Only.
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
Packing | Price | Stock | Quantity |
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5 mg | $118 | In stock | |
10 mg | $188 | In stock | |
25 mg | $328 | In stock | |
50 mg | $548 | In stock | |
100 mg | Get quote |
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ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively.
ML-60218 compromises the structural integrity of viroplasms and rotavirus double-layered particles, interferes with the formation of higher order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize.
M.Wt | 452.368 | |
Formula | C19H15Cl2N3O2S2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide |
1. Eichwald C, et al. J Virol. 2017 Nov 15. pii: JVI.01943-17.
2. Wu L, et al. Eukaryot Cell. 2003 Apr;2(2):256-64.
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