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Saframycin A

Chemical Structure : Saframycin A

CAS No.: 66082-27-7

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Saframycin A (NSC 325663)

Catalog No.: PC-70241Not For Human Use, Lab Use Only.

Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.
    Saframycin A shows potent antiproliferative effects in leukemia- and tumor-derived cells.
    Saframycin A induces nuclear translocation of GAPDH in cancer cells.

    Physicochemical Properties

    M.Wt 562.579
    Formula C29H30N4O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[[(6S,7R,9R,14aS,15R)-7-Cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxopropanamide

    References

    1. Xing C, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6.

    2. Ishiguro K, et al. Biochemistry. 1978 Jun 27;17(13):2545-50.

    3. Spencer JR, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4884-8.

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