| Cat. No. |
Product Name |
Information |
| PC-72020 |
ART558
DNA Polθ inhibitor
|
ART558 (ART-558) is a highly potent, selective, allosteric inhibitor of the polymerase function of DNA polymerase Polθ with IC50 of 7.9 nM. |
| PC-35725 |
SEC inhibitor KL-2
cyclin T1-AFF4 inhibitor
|
SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC. |
| PC-35724 |
SEC inhibitor KL-1
cyclin T1-AFF4 inhibitor
|
SEC inhibitor KL-1 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=3.48 uM) within SEC. |
| PC-43493 |
CX-5461
RNA Pol I inhibitor
|
Pidnarulex (CX-5461) is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I, selectively inhibits rRNA synthesis in HCT-116 cells with IC50 of 142 nM, 200-fold selectivity over Pol II. |
| PC-43167 |
SCR7
NHEJ inhibitor, DNA ligase IV inhibitor
|
SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I. |
| PC-63201 |
PNR-7-02
DNA Polη inhibitor
|
PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols. |
| PC-43056 |
BMH-21
RNA Pol I inhibitor
|
BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription. |
| PC-42973 |
Cycloheximide
Protein synthesis inhibitor
|
Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. |
| PC-62219 |
CX-3543
RNA Pol I inhibitor
|
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells. |
| PC-61350 |
Plicamycin
Sp1 inhibitor
|
Plicamycin (Mithramycin A, PA 144, NSC 24559) is a tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA, inhibits specificity protein 1 (Sp1) transcription factor. |
| PC-61229 |
ML-60218
RNA Pol III inhibitor
|
ML-60218 (ML60218) is a broad-spectrum, small molecule inhibitor of RNA polymerase (Pol) III with IC50 of 32 and 27 uM for Saccharomyces cerevisiae and human, respectively. |
| PC-70241 |
Saframycin A
|
Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro. |
