| Cat. No. |
Product Name |
Information |
| PC-45353 |
Bleomycin sulfate
|
An anticancer agent that acts by induction of DNA strand breaks. |
| PC-45751 |
COH-29
|
A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM. |
| PC-42295 |
Beaucage reagent
|
A potent DNA cleavage agent. |
| PC-43227 |
TH-588 hydrochloride
|
A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM. |
| PC-45105 |
TH-287 hydrochloride
|
A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM. |
| PC-45350 |
Actinomycin D
|
A chemotherapy agent that has the ability to inhibit transcription. |
| PC-22343 |
DNA ligase inhibitor L67
DNA ligase inhibitor
|
DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both. |
| PC-21698 |
Fraisinib
GARS1 inhibitor
|
Fraisinib is a specific and effective inhibitor of glycyl-tRNA synthetase 1 (GARS1), suppresses the synthesis of Ap4A by GARS1 and displays strong anti-tumoral potential. |
| PC-20939 |
RBI2
Ribosome biogenesis inhibitor
|
RBI2 (Ribosome biogenesis inhibitor 2) is a small molecule inhibitor of ribosome biogenesis inhibitor, potently inhibits pre-rRNA levels in A375 with IC50 of 169 nM. |
| PC-20598 |
DNA polymerase theta inhibitor
POLθ inhibitor
|
DNA polymerase theta inhibitor (POLθi) is a small-molecule DNA polymerase theta (POLθ) inhibitor, binds to an allosteric pocket in the thumb subdomain of POLθ, inhibits its polymerase activity. |
| PC-49362 |
ART812
Polθ inhibitor
|
ART812 (ART-812) is a selective small molecule DNA polymerase theta (Polθ) in vivo probe, recapitulates the phenotype of Polθ loss and is efficacious in a model of PARP inhibitor resistant TNBC in vivo. |
| PC-38801 |
Congo red
DNA Pol γ inhibitor
|
Congo red (Zinc 03830554) is a high-affinity small molecule targeting mitochondrial DNA polymerase gamma (Pol γ), selectively kills MLH1 deficient cancer cells. |
