| Cat. No. |
Product Name |
Information |
| PC-49348 |
RP-6685
DNA Polθ inhibitor
|
RP-6685 (RP6685) is a potent, selective and orally bioavailable inhibitor of DNA polymerase theta (Polθ) with IC50 of 5.8 nM in PicoGreen assay (0.3 nM Polθ enzyme). |
| PC-38801 |
Congo red
DNA Pol γ inhibitor
|
Congo red (Zinc 03830554) is a high-affinity small molecule targeting mitochondrial DNA polymerase gamma (Pol γ), selectively kills MLH1 deficient cancer cells. |
| PC-38571 |
L189
DNA ligase inhibitor
|
L189 is a small moelcule DNA ligase I, III and IV inhibitor with IC50 of 5, 9 and 5 uM, blocks DNA ligase I DNA binding activity with Ki of 5 uM. |
| PC-38570 |
L82-G17
DNA ligase I inhibitor
|
L82-G17 is a selective, uncompetitive inhibitor of DNA ligase I, inhibits the third step of the ligation reaction, phosphodiester bond formation. |
| PC-73404 |
Bersiporocin
PRS inhibitor
|
Bersiporocin (DWN 12088) is an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitor with antifibrotic effect. |
| PC-73357 |
Pyridostatin
G-quadruplex stabilizer
|
Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest. |
| PC-72917 |
IMT1B
POLRMT inhibitor
|
IMT1B (LDC203974) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT). |
| PC-72916 |
IMT1
POLRMT inhibitor
|
IMT1 (LDC195943) is a first-in-class specific inhibitor of mitochondrial transcription that target the human mitochondrial RNA polymerase (POLRMT). |
| PC-72020 |
ART558
DNA Polθ inhibitor
|
ART558 (ART-558) is a highly potent, selective, allosteric inhibitor of the polymerase function of DNA polymerase Polθ with IC50 of 7.9 nM. |
| PC-35725 |
SEC inhibitor KL-2
cyclin T1-AFF4 inhibitor
|
SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC. |
| PC-35724 |
SEC inhibitor KL-1
cyclin T1-AFF4 inhibitor
|
SEC inhibitor KL-1 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=3.48 uM) within SEC. |
| PC-43493 |
CX-5461
RNA Pol I inhibitor
|
Pidnarulex (CX-5461) is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I, selectively inhibits rRNA synthesis in HCT-116 cells with IC50 of 142 nM, 200-fold selectivity over Pol II. |
