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BMH-21

Chemical Structure : BMH-21

CAS No.: 896705-16-1

BMH-21 (BMH21)

Catalog No.: PC-43056Not For Human Use, Lab Use Only.

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription.

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Biological Activity

BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription.
BMH-21 inhibits the expression of 47S rRNA transcript with IC50 of 60 nM, blocks transcription of the rRNA precursor without affecting rRNA maturation, and causes segregation of nucleolar proteins.
BMH-21 causes proteasome-mediated degradation of RPA194 (Pol I catalytic subunit).
BMH-21 activates p53 and inhibits TP53 null and mutant cell lines with GI50 of 110 and 205 nM, respectively.

Physicochemical Properties

M.Wt 360.4091
Formula C21H20N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-

References

1. Peltonen K, et al. Cancer Cell. 2014 Jan 13;25(1):77-90.

2. Colis L, et al. J Med Chem. 2014 Jun 12;57(11):4950-61.

3. Colis L, et al. Oncotarget. 2014 Jun 30;5(12):4361-9.

4. Peltonen K, et al. Mol Cancer Ther. 2014 Nov;13(11):2537-46.

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