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Chemical Structure : PNR-7-02
Catalog No.: PC-63201Not For Human Use, Lab Use Only.
PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols.
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PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols.
PNR-7-02 binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η.
PNR-7-02 potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.
| M.Wt | 445.921 | |
| Formula | C24H16ClN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.
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