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PNR-7-02

Chemical Structure : PNR-7-02

CAS No.: 1633660-76-0

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PNR-7-02

Catalog No.: PC-63201Not For Human Use, Lab Use Only.

PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PNR-7-02 is a specific inhibitor of human DNA Polymerase η (hPol η) with IC50 of 8 uM, exhibits 5-10-fold specificity for hPol η over other replicative Pols.
    PNR-7-02 binds to a site on the little finger domain and interferes with the proper orientation of template DNA to inhibit hpol η.
    PNR-7-02 potentiates the effects of cisplatin in tumor cells accompanied with increased γH2AX formation.

    Physicochemical Properties

    M.Wt 445.921
    Formula C24H16ClN3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

    References

    1. Zafar MK, et al. Biochemistry. 2018 Feb 20;57(7):1262-1273.

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