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Chemical Structure : Cycloheximide
CAS No.: 66-81-9
Catalog No.: PC-42973Not For Human Use, Lab Use Only.
Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 mg | $55 | In stock | |
| 1 g | $75 | In stock | |
| 5 g | $115 | In stock |
Bulk size, bulk discount!
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Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively; block the elongation phase of eukaryotic translation, binds the ribosome and inhibits eEF2-mediated translocation; impairs memory more as footshock intensity increases, enhances memory in an inverted-U dose-response manner at low dose; also sensitizes COLO 205 cells to TNF-alpha-induced programmed cell death.
| M.Wt | 281.3474 | |
| Formula | C15H23NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: >33 mg/mL; H2O: 20 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
2,6-Piperidinedione, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]- |
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1. Schneider-Poetsch T, et al. Nat Chem Biol. 2010 Mar;6(3):209-217.
2. Gold PE, et al. Behav Brain Res. 2012 Aug 1;233(2):293-7.
3. Neeman M, et al. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5585-9.
4. Pajak B, et al. J Physiol Pharmacol. 2005 Jun;56 Suppl 3:101-18.
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