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Chemical Structure : Cycloheximide
CAS No.: 66-81-9
Catalog No.: PC-42973Not For Human Use, Lab Use Only.
Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $58 | In stock | |
| 250 mg | $88 | In stock | |
| 1 g | Get quote |
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Cycloheximide (Naramycin A, Actidione) is a widely-used protein synthesis inhibitor that inhibits protein biosynthesis in eukaryotic organisms with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively.
Cycloheximide blocks the elongation phase of eukaryotic translation, binds the ribosome and inhibits eEF2-mediated translocation.
Cycloheximide impairs memory more as footshock intensity increases, enhances memory in an inverted-U dose-response manner at low dose.
Cycloheximide also sensitizes COLO 205 cells to TNF-alpha-induced programmed cell death.
| M.Wt | 281.3474 | |
| Formula | C15H23NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: >33 mg/mL; H2O: 20 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
2,6-Piperidinedione, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]- |
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1. Schneider-Poetsch T, et al. Nat Chem Biol. 2010 Mar;6(3):209-217.
2. Gold PE, et al. Behav Brain Res. 2012 Aug 1;233(2):293-7.
3. Neeman M, et al. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5585-9.
4. Pajak B, et al. J Physiol Pharmacol. 2005 Jun;56 Suppl 3:101-18.
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