Chemical Structure : CX-3543
CAS No.: 865311-47-3
Catalog No.: PC-62219Not For Human Use, Lab Use Only.
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $198 | In stock | |
10 mg | $298 | In stock | |
25 mg | $488 | In stock | |
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CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells.
M.Wt | 604.67 | |
Formula | C35H33FN6O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide |
1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61.
2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32.
3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.
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