Chemical Structure : CX-3543
Catalog No.: PC-62219Not For Human Use, Lab Use Only.
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.
Blood Cancer
Phase 2 Discontinued
M.Wt | 604.67 | |
Formula | C35H33FN6O3 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61.
2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32.
3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright