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CX-3543

Chemical Structure : CX-3543

CAS No.: 865311-47-3

CX-3543 (Quarfloxin;Itarnafloxin)

Catalog No.: PC-62219Not For Human Use, Lab Use Only.

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting Pol I transcription and inducing apoptosis in cancer cells.

Blood Cancer

Phase 2 Discontinued

Physicochemical Properties

M.Wt 604.67
Formula C35H33FN6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

References

1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61.

2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32.

3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.

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