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Chemical Structure : Pyridostatin
CAS No.: 1085412-37-8
Catalog No.: PC-73357Not For Human Use, Lab Use Only.
Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $148 | In stock | |
| 100 mg | $428 | In stock | |
| 200 mg | $728 | In stock | |
| 1 g | Get quote |
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Pyridostatin (RR82) is a high-affinity G-quadruplex-stabilizing small molecule (Kd=490 nM), promotes the folding of telomeric G-quadruplexes, induces DNA damage and cell cycle arrest.
Pyridostatin targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.
Pyridostatin also targets telomeric G-quadruplexes, inducing telomerase dysfunction.
Pyridostatin activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).
Pyridostatin decreases the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1) synthesis.
| M.Wt | 596.6 | |
| Formula | C31H32N8O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide |
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1. Koirala D, et al. Nat Chem. 2011 Aug 28;3(10):782-7.
2. McLuckie KI, et al. J Am Chem Soc. 2013 Jul 3;135(26):9640-3.
3. Rodriguez R, et al. Nat Chem Biol. 2012 Feb 5;8(3):301-10.
4. Murat P, et al. Nat Chem Biol. 2014 May;10(5):358-64.
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