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Chemical Structure : DNA ligase inhibitor L67
CAS No.: 325970-71-6
Catalog No.: PC-22343Not For Human Use, Lab Use Only.
DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | Get quote |
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DNA ligase inhibitor L67 is a competitive DNA ligase inhibitor, effectively inhibits DNA ligases I/III with IC50 of 10 uM for both.
L67 treatment causes nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS.
L67 also activates the Caspase 1-dependent apoptosis pathway in cancer cells.
| M.Wt | 486.12 | |
| Formula | C16H14Br2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide |
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1. Sallmyr A, et al. Cancer Res. 2016 Sep 15;76(18):5431-41.
2. Chen X, et al. Cancer Res. 2008 May 1;68(9):3169-77.
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