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Chemical Structure : COH29
CAS No.: 1190932-38-7
Catalog No.: PC-45751Not For Human Use, Lab Use Only.
COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
COH29 overcomes hydroxyurea and gemcitabine resistance in cancer cells, effectively inhibits proliferation of most cell lines in the NCI 60 human cancer panel.
COH29 inhibits nonhomologous end joining (NHEJ) efficiency in HCC1937 cells.
COH29 reduced tumor growth in mouse xenograft models of human cancer.
| M.Wt | 420.4378 | |
| Formula | C22H16N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Benzamide,N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy- |
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1. Zhou B, et al. Cancer Res. 2013 Nov 1;73(21):6484-93.
2. Chen MC, et al. Mol Pharmacol. 2015 Jun;87(6):996-1005.
3. Zhang H, et al. BMC Cancer. 2014 Sep 11;14:664.
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