COH29 is a small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
COH29 overcomes hydroxyurea and gemcitabine resistance in cancer cells, effectively inhibits proliferation of most cell lines in the NCI 60 human cancer panel.
COH29 inhibits nonhomologous end joining (NHEJ) efficiency in HCC1937 cells.
COH29 reduced tumor growth in mouse xenograft models of human cancer.
