Minnelide |CAS:1254702-87-8 Probechem Biochemicals

Chemical Structure : Minnelide

CAS No.: 1254702-87-8

Minnelide (14-O-phosphonooxymethyltriptolide disodium salt)

Catalog No.: PC-70029Not For Human Use, Lab Use Only.

Minnelide is a water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival, induces and promotes apoptosis.

Packing	Price	Stock
5 mg	$198	In stock
10 mg	$328	In stock
25 mg	$548	In stock
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Biological Activity

Minnelide is a water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival, induces and promotes apoptosis.
Minnelide efficiently downregulates both CD133(-) and CD133(+) population in the tumors, resulting in a 60% decrease in tumor volume.
Minnelide also is very effective as a therapeutic option against Castration Resistant Prostate Cancer (CRPC).

Physicochemical Properties

M.Wt	514.374
Formula	C21H25Na2O10P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (((5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl)oxy)methyl phosphate

References

1. Chugh R, et al. Sci Transl Med. 2012 Oct 17;4(156):156ra139.

2. Banerjee S, et al. Clin Cancer Res. 2014 May 1;20(9):2388-99.

3. Isharwal S, et al. Prostate. 2017 May;77(6):584-596.

Minnelide (14-O-phosphonooxymethyltriptolide disodium salt)

Biological Activity

Physicochemical Properties

References

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