RP-4029 | DNA Polθ inhibitor | Probechem Biochemicals

Chemical Structure : RP-4029

RP-4029 (RP4029)

Catalog No.: PC-26267Not For Human Use, Lab Use Only.

RP-4029 is a potent, selective and covalent inhibitor of DNA polymerase θ (Polθ) with IC50 of 0.013 nM and 6.6 nM for human and mouse Polθ respectively, forms a covalent adduct with Cys2411 of human Polθ.

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Biological Activity

Physicochemical Properties

M.Wt	623.57
Formula	C29H23F6N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-(2,4-bis(trifluoromethyl)phenyl)-N-phenylacetamido)but-2-yn-1-yl)-2-(vinylsulfonamido)benzamide

References

1. Bubenik M, et al. ACS Med Chem Lett. 2026 Jan 7;17(2):433-440.

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RP-4029 (RP4029)

Biological Activity

Physicochemical Properties

References

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