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Chemical Structure : BTB-1
CAS No.: 86030-08-2
Catalog No.: PC-49285Not For Human Use, Lab Use Only.
BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
BTB-1 decreased the expression of viral RNAs and proteins, and the production of infectious viral particles, while overexpression of KIF18A enhanced the replication of influenza A virus (IAV).
BTB-1 treatment attenuated the activation of AKT, p38 MAPK, SAPK and Ran-binding protein 3 (RanBP3), which led to the prevention of the nuclear export of viral ribonucleoprotein complexes.
BTB-1 greatly improved the viability of IAV-infected mice.
BTB-1 treatment strongly inhibited the differentiation of mouse bone marrow (BM) cells into dendritic cells (DCs) in a dose-dependent manner.
Treatment of immature DCs with BTB-1 significantly impaired the expression of activation markers on DCs including MHC class I, CD80, and CD86 upon TLR4 or TLR7 treatment.
| M.Wt | 297.72 | |
| Formula | C12H8ClNO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene |
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1. Braun J, et al. ACS Chem Biol. 2015 Feb 20;10(2):554-60.
2. Catarinella M, et al. Angew Chem Int Ed Engl. 2009;48(48):9072-6.
3. Locke J, et al. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548.
4. Cho YB, et al. J Cell Mol Med. 2020 May;24(10):5463-5475.
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