Catalog No.: PC-49285Not For Human Use, Lab Use Only.
BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
BTB-1 decreased the expression of viral RNAs and proteins, and the production of infectious viral particles, while overexpression of KIF18A enhanced the replication of influenza A virus (IAV).
BTB-1 treatment attenuated the activation of AKT, p38 MAPK, SAPK and Ran-binding protein 3 (RanBP3), which led to the prevention of the nuclear export of viral ribonucleoprotein complexes.
BTB-1 greatly improved the viability of IAV-infected mice.
BTB-1 treatment strongly inhibited the differentiation of mouse bone marrow (BM) cells into dendritic cells (DCs) in a dose-dependent manner.
Treatment of immature DCs with BTB-1 significantly impaired the expression of activation markers on DCs including MHC class I, CD80, and CD86 upon TLR4 or TLR7 treatment.
Physicochemical Properties
M.Wt
297.72
Formula
C12H8ClNO4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
References
1. Braun J, et al. ACS Chem Biol. 2015 Feb 20;10(2):554-60.
2. Catarinella M, et al. Angew Chem Int Ed Engl. 2009;48(48):9072-6.
3. Locke J, et al. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9539-E9548.
4. Cho YB, et al. J Cell Mol Med. 2020 May;24(10):5463-5475.
