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Kif15-IN-1

Chemical Structure : Kif15-IN-1

CAS No.: 672926-32-8

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Kif15-IN-1

Catalog No.: PC-63578Not For Human Use, Lab Use Only.

Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation.

Physicochemical Properties

M.Wt 430.479
Formula C20H22N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (S)-2-(2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-3-methylbutanamido)-4-methylthiazole-5-carboxylate

References

1. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.

2. Milic B, et al. Proc Natl Acad Sci U S A. 2018 Apr 27. pii: 201801242.

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