| Cat. No. |
Product Name |
Information |
| PC-62405 |
MAC1
Eg5 rescuer
|
MAC1 (Monastrol Antagonizing Compound 1) is a small molecule that can rescue spindle bipolarity in cells lacking Eg5 activity. |
| PC-62374 |
AZ82
KIFC1 inhibitor
|
AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM. |
| PC-62341 |
BRD 9876
Eg5 inhibitor
|
BRD 9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM, selectively inhibits microtubule-bound Eg5 and inhibits multiple myeloma cell growth (IC50=2.2 uM). |
| PC-62340 |
S-Trityl-L-cysteine
Eg5 inhibitor
|
S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM). |
| PC-62339 |
PVZB1194
KSP inhibitor
|
PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM. |
| PC-62338 |
MK-0731
KSP inhibitor
|
MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM. |
| PC-62337 |
MK-8267
KSP inhibitor
|
MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM. |
| PC-62336 |
GSK-1
KSP inhibitor
|
GSK-1 is an ATP-competitive inhibitor of the mitotic kinesin KSP with HCT116 cell IC50 of 36 nM. |
| PC-70280 |
Propofol
Kinesin inhibitor
|
Propofol (2,6-Diisopropylphenol) is a widely used general anesthetic to induce and maintain anesthesia, also inhibits kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC. |
| PC-70049 |
KSP-IA
KSP inhibitor
|
KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM. |
| PC-70048 |
CK-0106023
KSP inhibitor
|
CK-0106023 (CK0106023) is a potent, specific, allosteric inhibitor of KSP motor domain ATPase with Ki of 12 nM. |
| PC-70047 |
HR22C16
Eg5 inhibitor
|
HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins. |
