Catalog No.: PC-42882Not For Human Use, Lab Use Only.
SB-743921 (SB-743921) is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.
SB-743921 (SB-743921) is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.
SB-743921 also shows high affinity for mouse KSP with Ki of 0.12 nM.
SB-743921 blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death in cancer cells, demonstrates improved potency over ispinesib in both biochemical and cellular assays.
SB-743921 shows a broad spectrum of tumor inhibition in multiple cancer models.
