Catalog No.: PC-70280Not For Human Use, Lab Use Only.
Propofol (2,6-Diisopropylphenol) is a widely used general anesthetic to induce and maintain anesthesia, also inhibits kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC.
Propofol (2,6-Diisopropylphenol) is a widely used general anesthetic to induce and maintain anesthesia, also inhibits kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC.
Propofol (2,6-Diisopropylphenol) influences ligand-gated channels, including the GABAA receptor and others.
Propofol (2,6-Diisopropylphenol) also inhibits conventional kinesin-1 KIF5B and kinesin-2 KIF3AB and KIF3AC, causing a significant reduction in the distances that these processive kinesins can travel without an effect on velocity (EC50<100 nM).
Physicochemical Properties
M.Wt
178.271
Formula
C12H18O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Phenol, 2,6-diisopropyl- (6CI,8CI)
References
1. Bensel BM, et al. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4281-E4287.
2. Jin WZ, et al. Eur J Pharmacol. 2016 Oct 5;788:37-44.
3. Eaton MM, et al. Curr Neuropharmacol. 2016;14(7):772-80.
