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MK-8267

Chemical Structure : MK-8267

CAS No.: 1146209-50-8

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MK-8267 (SCH 2047069, MK8267)

Catalog No.: PC-62337Not For Human Use, Lab Use Only.

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
    MK-8267 inhibits a broader panel of 57 different tumor cell lines with IC50 <30 nM.
    MK-8267 shows significant brain uptake in mouse and rat with brain/plasma AUC ratio of 4 in rats, demonstrates anti-tumor activities in the tumor xenograft mouse model.

    Physicochemical Properties

    M.Wt 439.429
    Formula C20H17F4N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one

    References

    1. Mansoor UF, et al. Bioorg Med Chem. 2015 May 15;23(10):2424-34.

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