S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM).
S-Trityl-L-cysteine induces mitotic arrest in HeLa cells with an IC50 of 700 nM, and displays antitumor activity.
Physicochemical Properties
M.Wt
363.47
Formula
C22H21NO2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
S-(Triphenylmethyl)-L-cysteine
References
1. Brier S, et al. Biochemistry. 2004 Oct 19;43(41):13072-82.
2. DeBonis S, et al. Mol Cancer Ther. 2004 Sep;3(9):1079-90.
3. Zhao J, et al. Am J Cancer Res. 2014 Jan 15;4(1):42-52.
