Kinesore is a small molecule activator of kinesin-1 that inhibits KLC2-SKIP interaction with IC50 of 101 uM, Ki of 49 uM.
Kinesore inhibits kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptors, yet activates kinesin-1's function of controlling microtubule dynamics in cells.
Kinesore induces the remodeling of the microtubule network.
