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Kinesore

Chemical Structure : Kinesore

CAS No.: 363571-83-9

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Kinesore

Catalog No.: PC-62648Not For Human Use, Lab Use Only.

Kinesore is a small molecule activator of kinesin-1 that inhibits KLC2-SKIP interaction with IC50 of 101 uM, Ki of 49 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Kinesore is a small molecule activator of kinesin-1 that inhibits KLC2-SKIP interaction with IC50 of 101 uM, Ki of 49 uM.
Kinesore inhibits kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptors, yet activates kinesin-1's function of controlling microtubule dynamics in cells.
Kinesore induces the remodeling of the microtubule network.

Physicochemical Properties

M.Wt 536.18
Formula C20H16Br2N4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide

References

1. Randall TS, et al. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13738-13743.

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