KSP-IA | KSP inhibitor | Probechem Biochemicals

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Chemical Structure : KSP-IA

KSP-IA (KSP inhibitor)

Catalog No.: PC-70049Not For Human Use, Lab Use Only.

KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM.
KSP-IA has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM).
KSP-IA induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells.
KSP-IA sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation.

Physicochemical Properties

M.Wt	356.417
Formula	C21H22F2N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutan-1-one

References

1. Tao W, et al. Cancer Cell. 2005 Jul;8(1):49-59.

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