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PVZB1194

Chemical Structure : PVZB1194

CAS No.: 1141768-04-8

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PVZB1194 (PVZB-1194)

Catalog No.: PC-62339Not For Human Use, Lab Use Only.

PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.
    PVZB1194  inhibits HeLa cell proliferation with IC50 of 5.5 uM.
    PVZB1194  potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.

    Physicochemical Properties

    M.Wt 319.274
    Formula C13H9F4NO2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[3-fluoro-4-(trifluoromethyl)phenyl]benzenesulfonamide

    References

    1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61.

    2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.

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