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Chemical Structure : PVZB1194
Catalog No.: PC-62339Not For Human Use, Lab Use Only.
PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.
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PVZB1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM.
PVZB1194 inhibits HeLa cell proliferation with IC50 of 5.5 uM.
PVZB1194 potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.
| M.Wt | 319.274 | |
| Formula | C13H9F4NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61.
2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36.
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