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BRD9876

Chemical Structure : BRD9876

CAS No.: 32703-82-5

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BRD9876 (BRD 9876)

Catalog No.: PC-62341Not For Human Use, Lab Use Only.

BRD9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM, selectively inhibits microtubule-bound Eg5 and inhibits multiple myeloma cell growth (IC50=2.2 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BRD9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM, selectively inhibits microtubule-bound Eg5 and inhibits multiple myeloma cell growth (IC50=2.2 uM).
BRD9876 enhances Eg5-mediated microtubule stabilization.

Physicochemical Properties

M.Wt 234.302
Formula C16H14N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-tert-Butyl-2,3-naphthalenedicarbonitrile

References

1. Chen GY, et al. ACS Chem Biol. 2017 Apr 21;12(4):1038-1046.

2. Chattopadhyay S, et al. Cell Rep. 2015 Feb 4. pii: S2211-1247(15)00030-3.

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