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Chemical Structure : Filanesib
CAS No.: 885060-09-3
Catalog No.: PC-73188Not For Human Use, Lab Use Only.
Filanesib (ARRY-520) is a potent, selective and noncompetitive kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Filanesib (ARRY-520) is a potent, selective and noncompetitive kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
Filanesib (ARRY-520) induces mitotic arrest in multiple cell lines.
Filanesib (ARRY-520) exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors, with EC50 of 0.4-14.4 nM.
Filanesib (ARRY-520) causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells, induces caspase-2 activation.
Filanesib (ARRY-520) demonstrates anti-tumor activitiy in vivo.
| M.Wt | 420.48 | |
| Formula | C20H22F2N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide |
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1. Christine Lemieux, et al. AACR Annual Meeting. 2007.
2. Woessner R, et al. Anticancer Res. 2009 Nov;29(11):4373-80.
3. Carter BZ, et al. Leukemia. 2009 Oct;23(10):1755-62.
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