Sovilnesib (AMG650) | KIF18A inhibitor

Chemical Structure : AMG650

CAS No.: 2410796-79-9

AMG650 (Sovilnesib, AMG 650)

Catalog No.: PC-72904Not For Human Use, Lab Use Only.

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A with IC50 of 71 nM.

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$398	In stock
50 mg	$598	In stock
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Biological Activity

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A with IC50 of 71 nM.
KIF18A is a mitotic kinesin motor protein that regulates chromosome positioning during cell division and is overexpressed in a subset of human cancers.

Physicochemical Properties

M.Wt	564.653
Formula	C26H34F2N6O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

References

1, Patent WO2021211549.

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AMG650 (Sovilnesib, AMG 650)

Biological Activity

Physicochemical Properties

References

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