Azo-EMD

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Chemical Structure : Azo-EMD

Catalog No.: PC-72726Not For Human Use, Lab Use Only.

Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis.
Under UV light conditions, HeLa cells undergo mitotic arrest, as evidenced by the formation of a monopolar spindle.

Physicochemical Properties

M.Wt	656.754
Formula	C37H39F3N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(methyl(4-((E)-phenyldiazenyl)benzyl)amino)ethyl)-3-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)urea

References

1. Anna C Impastato, et al. Angew Chem Int Ed Engl. 2022 Feb 21;61(9):e202115846.

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Azo-EMD

Biological Activity

Physicochemical Properties

References

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