KIF18A inhibitor 24

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Chemical Structure : KIF18A inhibitor 24

CAS No.: 2600577-49-7

Catalog No.: PC-72268Not For Human Use, Lab Use Only.

KIF18A inhibitor 24 is a highly potent, in vivo active inhibitor of mitotic kinesin KIF18A with IC50 of 61 nM.

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Biological Activity

KIF18A inhibitor 24 is a highly potent, in vivo active inhibitor of mitotic kinesin KIF18A with IC50 of 61 nM.
KIF18A inhibitor 24 binds at the interface of KIF18A and tubulin.
KIF18A inhibitor 24 exhibits significant mitotic arrest in MDA-MB-157 mitotic cells with EC50 of 11 nM, followed by cell death either in mitosis or in the subsequent interphase, which is sustained for 24 h.

Physicochemical Properties

M.Wt	574.755
Formula	C28H38N4O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(N-(tert-butyl)sulfamoyl)phenyl)-4-((1-methylcyclopropane)-1-sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

References

1. Nuria A Tamayo, et al. J Med Chem. 2022 Mar 24;65(6):4972-4990.

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