Orvanesib (VLS-1488, KIF18A-IN-6) | KIF18A inhibitor

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Chemical Structure : VLS-1488

CAS No.: 2914879-10-8

VLS-1488 (Orvanesib, VLS1488, KIF18A-IN-6)

Catalog No.: PC-25961Not For Human Use, Lab Use Only.

Orvanesib (VLS-1488, KIF18A-IN-6) is a potent, selective and orally active KIF18A inhibitor, inhibits KIF18A microtubule-dependent ATPase activity with IC50 of 16 nM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Orvanesib (VLS-1488, KIF18A-IN-6) is a potent, selective and orally active KIF18A inhibitor, inhibits KIF18A microtubule-dependent ATPase activity with IC50 of 16 nM.

Physicochemical Properties

M.Wt	559.74
Formula	C28H37N3O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(tert-butyl)-3-(5''-(ethylsulfonamido)dispiro[cyclopropane-1,1'-cyclohexane-4',3''-indoline]-1''-carbonyl)benzenesulfonamide

References

1. Patent WO2023028564 (Compound 134).

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VLS-1488 (Orvanesib, VLS1488, KIF18A-IN-6)

Biological Activity

Physicochemical Properties

References

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