Chemical Structure : ATX020
CAS No.:
3030452-08-2
ATX020
(ATX-020)
Catalog No.: PC-25729Not For Human Use, Lab Use Only.
ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively.
ATX020 displays little to no activity against CENP-E, Eg5, KIF15, KIF18B and KIF19 (IC50>5 uM).
ATX020 displays potent antiproliferative activity against the KIF18A-sensitive OVCAR-8 and AU565 cell lines with IC50 of 0.09 and 0.21 uM respectively.
ATX020 (30 and 100 mg/kg, po q.d. dosing) displays robust tumor growth inhibition on OVCAR-3 CDX tumor model.
Physicochemical Properties
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M.Wt
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581.75
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Formula
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C26H37F2N5O4SSi
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(4,4-difluorocyclohexyl)-6-methylpyrimidin-4-yl)-2-(4,4-dimethyl-1,4-azasilinan-1-yl)-4-((2-hydroxyethyl)sulfonamido)benzamide
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References
1. Sparling BA, et al. ACS Med Chem Lett. 2025 Oct 27;16(11):2309-2319.
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