Catalog No.: PC-25729Not For Human Use, Lab Use Only.
ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively.
ATX020 (ATX-020) is a potent, selective and orally efficacious KIF18A (kinesin-like protein 18A) inhibitor with IC50 of 0.11 uM and 0.16 uM for human and rat KIF18A respectively.
ATX020 displays little to no activity against CENP-E, Eg5, KIF15, KIF18B and KIF19 (IC50>5 uM).
ATX020 displays potent antiproliferative activity against the KIF18A-sensitive OVCAR-8 and AU565 cell lines with IC50 of 0.09 and 0.21 uM respectively.
ATX020 (30 and 100 mg/kg, po q.d. dosing) displays robust tumor growth inhibition on OVCAR-3 CDX tumor model.
