KIF18A inhibitor 19d

Chemical Structure : KIF18A inhibitor 19d

Catalog No.: PC-28101Not For Human Use, Lab Use Only.

KIF18A inhibitor 19d is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 52 nM, exhibits single-digit nanomolar antiproliferative activity in CIN-high OVCAR-3 cells (EC50=3.4 nM), induces tumor regression in the OVCAR-3 xenograft model.

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Biological Activity

KIF18A inhibitor 19d is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 52 nM, exhibits single-digit nanomolar antiproliferative activity in CIN-high OVCAR-3 cells (EC50=3.4 nM), induces tumor regression in the OVCAR-3 xenograft model.

Physicochemical Properties

M.Wt	585.67
Formula	C28H33F2N7O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(8-(4,4-difluoropiperidin-1-yl)imidazo[1,2-a]pyrazin-6-yl)-4-(methylsulfonamido)-2-(3-azaspiro[bicyclo[3.2.1]octane-8,1'-cyclopropan]-3-yl)benzamide

References

1. Ao W, et al. Eur J Med Chem. 2026 Sep 7;320:119313.

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