Chemical Structure : LAVR-289
CAS No.:
LAVR-289
(LAVR289)
Catalog No.: PC-24684Not For Human Use, Lab Use Only.
LAVR-289 is a novel acyclic nucleoside phosphonate that effectively inhibits viral replication by targeting a specific domain in the poxvirus DNA polymerase, exhibits antiviral activity against HCMV, vaccinia virus (VV) and HSV-1 (TK-) with EC50 of 21 nM, 50 nM and 8.5 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LAVR-289 is a novel acyclic nucleoside phosphonate that effectively inhibits viral replication by targeting a specific domain in the poxvirus DNA polymerase, exhibits antiviral activity against HCMV, vaccinia virus (VV) and HSV-1 (TK-) with EC50 of 21 nM, 50 nM and 8.5 nM respectively.
LAVR-289 inhibits VACV, CPXV, MPXV, and ASFV in vitro at nanomolar concentrations by acting at the replication stage and directly targeting the viral DNA polymerase.
LAVR-289 potent inhibits VZV wild-type (TK+) (EC50 0.0035 μM, SI 740) and for thymidine kinase VZV deficient strains (EC50 0.018 μM, SI 145), with a low morphological toxicity in cell culture at 100 μM.
LAVR-289 demonstrated protective efficacy in infected animals without toxicity.
Physicochemical Properties
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M.Wt
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730.88
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Formula
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C35H63N4O10P
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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