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Chemical Structure : GW 275175X
Catalog No.: PC-61947Not For Human Use, Lab Use Only.
GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation.
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GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation; shows antiviral efficacy against AD169 laboratory strain in DNA hybridization assays with IC50 of 0.7 uM, against 10 clinically relevant HCMV isolates with IC50 of 0.16-2.21 uM, and little or no activity against HSV-1, HSV-2 and varicella zoster virus; inhibits viral DNA maturation in a dose-dependent fashion.
| M.Wt | 398.034 | |
| Formula | C12H11BrCl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Williams SL, et al. Antimicrob Agents Chemother. 2003 Jul;47(7):2186-92.
2. Underwood MR, et al. Antimicrob Agents Chemother. 2004 May;48(5):1647-51.
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