Brincidofovir (CMX001) | Antiviral agent

Chemical Structure : Brincidofovir

CAS No.: 444805-28-1

Brincidofovir (CMX001, Cidofovir HDP, HDP-CDV)

Catalog No.: PC-62054Not For Human Use, Lab Use Only.

Brincidofovir (CMX 001, Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir that shows activity against all five families of dsDNA viruses that cause human morbidity and mortality, including orthopoxviruses such as variola virus, the cause of human smallpox.

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10 mg	$128	In stock
25 mg	$198	In stock
50 mg	$348	In stock
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Biological Activity

Brincidofovir (CMX001, Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir that shows activity against all five families of dsDNA viruses that cause human morbidity and mortality,including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, HSV, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections.

Brincidofovir has a number of advantages for treatment of smallpox in an emergency including greater potency in vitro against all dsDNA viruses that cause human disease, a high genetic barrier to resistance, convenient oral administration as a tablet or liquid, and no evidence to date of nephrotoxicity in either animals or humans.

Physicochemical Properties

M.Wt	561.701
Formula	C27H52N3O7P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(hexadecyloxy)propyl hydrogen ((((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonate

References

1. Toth K, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7293-7.

2. Lanier R, et al. Viruses. 2010 Dec;2(12):2740-2762.

3. McMullan LK, et al. Antiviral Res. 2016 Jan;125:71-8.

Brincidofovir (CMX001, Cidofovir HDP, HDP-CDV)

Biological Activity

Physicochemical Properties

References

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