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Chemical Structure : CIGB-300
Catalog No.: PC-72167Not For Human Use, Lab Use Only.
CIGB-300 (P15-Tat) is a cell-permeable cyclic peptide that modulates CK2 (CSNK2) activity by binding to the phosphoacceptor site on CK2 targets, abrogates the CK2 phosphorylation by blocking recombinant substrates in vitro.
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CIGB-300 (P15-Tat) is a cell-permeable cyclic peptide that modulates CK2 (CSNK2) activity by binding to the phosphoacceptor site on CK2 targets, abrogates the CK2 phosphorylation by blocking recombinant substrates in vitro.
CIGB-300 (P15-Tat) induced apoptosis as evidenced by rapid caspase activation and cellular cytotoxicity in a variety of tumor cell lines (HSCLC H-82 cell IC50=20 uM).
CIGB-300 (P15-Tat) demonstrated substantial regression of the tumor mass C57BL6 mice bearing day 7-established solid tumors.
CIGB-300 (P15-Tat) reduced breast cancer cell growth in MDA-MB-231, MCF-7 and F3II cells, exerting a pro-apoptotic action and cell cycle arrest. CIGB-300 decreased cell adhesion, migration and clonogenic capacity of malignant cells.
CIGB-300 may interfere with the SARS-CoV-2 life cycle within infected human cells.
| M.Wt | 3060.60 | |
| Formula | C127H215N53O30S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in MDSO |
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1. Perea SE, et al. Mol Cell Biochem. 2008 Sep;316(1-2):163-7.
2. Silvio E Perea, et al. Cancer Res. 2004 Oct 1;64(19):7127-9.
3. Miranda J, et al. Mol Med. 2021 Dec 20;27(1):161.
4. Gottardo MF, et al. Sci Rep. 2020 Sep 7;10(1):14689.
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