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Chemical Structure : ON108110
Catalog No.: PC-36054Not For Human Use, Lab Use Only.
ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).
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ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).
ON108110 reduces replication of influenza A virus in a dose-dependent manner by suppressing viral RNA synthesis, also inhibits other viruses including vesicular stomatitis virus and Newcastle disease virus.
ON108110 inhibits MCL and T-ALL cell growth (GI50 values of 0.2-3 uM), inhibits CK2 and CDK4/6 mediated oncogenic signaling.
| M.Wt | 374.342 | |
| Formula | C17H11FN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Padgaonkar A, et al. Oncotarget. 2018 Dec 28;9(102):37753-37765.
2. Martinez-Gil L, et al. Antiviral Res. 2013 Oct;100(1):29-37.
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