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ON108110

Chemical Structure : ON108110

CAS No.: 1415599-79-9

ON108110 (ON-108110, ON 108110)

Catalog No.: PC-36054Not For Human Use, Lab Use Only.

ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ON108110 (ON-108110, ON 108110) is a novel multi-kinase inhibitor of protein kinase CK2 (CK2α1/2, IC50=3/2 nM) as well as CDK4/6 (IC50=2-24 nM).
    ON108110 reduces replication of influenza A virus in a dose-dependent manner by suppressing viral RNA synthesis, also inhibits other viruses including vesicular stomatitis virus and Newcastle disease virus.
    ON108110 inhibits MCL and T-ALL cell growth (GI50 values of 0.2-3 uM), inhibits CK2 and CDK4/6 mediated oncogenic signaling.

    Physicochemical Properties

    M.Wt 374.342
    Formula C17H11FN2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (Z)-4-((6-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-ylidene)methyl)-2-nitrophenyl acetate

    References

    1. Padgaonkar A, et al. Oncotarget. 2018 Dec 28;9(102):37753-37765.

    2. Martinez-Gil L, et al. Antiviral Res. 2013 Oct;100(1):29-37.

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