Catalog No.: PC-72809Not For Human Use, Lab Use Only.
SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9).
SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9).
Treatment of the HEK293T-ACE2 cells with 1 μM of the CSNK2A chemical probe SGC-CK2-1 or CSNK2A inhibitor 2 resulted in a 70–80% decrease in spike protein uptake.
Chemical probe SGC-CK2-1 showed inhibition of virus replication at nanomolar doses where it has remarkably high kinase selectivity.
