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Chemical Structure : SGC-CK2-1
CAS No.: 2470424-39-4
Catalog No.: PC-72809Not For Human Use, Lab Use Only.
SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SGC-CK2-1 is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2/CK2, pIC50=8.3), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=6.9).
Treatment of the HEK293T-ACE2 cells with 1 μM of the CSNK2A chemical probe SGC-CK2-1 or CSNK2A inhibitor 2 resulted in a 70–80% decrease in spike protein uptake.
Chemical probe SGC-CK2-1 showed inhibition of virus replication at nanomolar doses where it has remarkably high kinase selectivity.
| M.Wt | 375.436 | |
| Formula | C20H21N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-2-methylphenyl)propionamide |
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1. Carrow I Wells, et al. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10.
2. Xuan Yang, et al. bioRxiv. 2022 Jan 4;2022.01.03.474779.
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