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KDX1381

Chemical Structure : KDX1381

CAS No.: 2757728-47-3

KDX1381 (KDX-1381)

Catalog No.: PC-24840Not For Human Use, Lab Use Only.

KDX1381 is a potent, selective bivalent CK2α inhibitor with IC50 of 17 nM, selecitve over a panel of over 400 protein and lipid kinases.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

KDX1381 is a potent, selective bivalent Casein Kinase 2α (CK2α) inhibitor with IC50 of 17 nM, selecitve over a panel of over 400 protein and lipid kinases.
KDX1381 is 10-fold more potent toward CK2α than CK2α'.
KDX1381 modulated CK2 signaling in a concentration-dependent manner across multiple tumor cell lines.
KDX1381 impaired the viability of cancer cells while sparing nontransformed counterparts.
KDX1381 induced time-dependent suppression of CK2 signaling observed in tumor tissues.

Physicochemical Properties

M.Wt 634.70
Formula C32H32F2N6O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(4-((4-(2-acetyl-5-fluoro-1H-indol-3-yl)-1H-1,2,3-triazol-1-yl)methyl)piperidin-1-yl)ethyl)-2'-fluoro-6'-hydroxy-[1,1'-biphenyl]-4-sulfonamide

References

1. Marlhoux L, et al. J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.5c00695.

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