Chemical Structure : KDX1381
CAS No.:
2757728-47-3
KDX1381
(KDX-1381)
Catalog No.: PC-24840Not For Human Use, Lab Use Only.
KDX1381 is a potent, selective bivalent CK2α inhibitor with IC50 of 17 nM, selecitve over a panel of over 400 protein and lipid kinases.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KDX1381 is a potent, selective bivalent Casein Kinase 2α (CK2α) inhibitor with IC50 of 17 nM, selecitve over a panel of over 400 protein and lipid kinases.
KDX1381 is 10-fold more potent toward CK2α than CK2α'.
KDX1381 modulated CK2 signaling in a concentration-dependent manner across multiple tumor cell lines.
KDX1381 impaired the viability of cancer cells while sparing nontransformed counterparts.
KDX1381 induced time-dependent suppression of CK2 signaling observed in tumor tissues.
Physicochemical Properties
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M.Wt
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634.70
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Formula
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C32H32F2N6O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(4-((4-(2-acetyl-5-fluoro-1H-indol-3-yl)-1H-1,2,3-triazol-1-yl)methyl)piperidin-1-yl)ethyl)-2'-fluoro-6'-hydroxy-[1,1'-biphenyl]-4-sulfonamide
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References
1. Marlhoux L, et al. J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.5c00695.
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