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Request The Product List ofMDM2-p53 MDM2-p53

Cat. No. Product Name CAS No. Information
PC-38124

NSC194598

5358-76-9 NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo.
PC-42959

AMG 232

1352066-68-2 Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM.
PC-61494

COTI-2

1039455-84-9 COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.
PC-61324

HL001

1186371-31-2 HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.
PC-60302

DS-3032b

1398568-47-2 DS-3032b is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
PC-70003

HDM-201

1448867-41-1 HDM-201 (NVP-HDM 201, Siremadlin) is a highly potent p53-MDM2 interaction inhibitor with biochemical IC50 of 0.13 nM, cellular IC50 of 90 nM.
PC-42100

Nutlin-3a

675576-98-4 Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.

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